Thursday, 3 November 2011

Vivid descriptions of faces 'don't have to go into detail'

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ScienceDaily (Oct. 21, 2011) — Celebrated writers such as Charles Dickens and George Eliot described characters' faces vividly without going into detail about their features, according to a research group led at Strathclyde.

Experts in literature, psychology, neurology and music suggested that vividness can be created not only by describing individual features, such as the eyes, nose or chin, but by the strength of readers' feelings about how a person is depicted.

These feelings may be triggered by the 'mirror neuron system,' in which people who see an action being performed have the same regions of the brain activated as are needed to perform the action itself- for example, by flinching when they see someone injured.

The researchers illustrated their theory by highlighting descriptions of characters in works by writers including Dickens, Eliot, Geoffrey Chaucer and Sir Walter Scott. They found that, in many cases, the face was not explicitly mentioned but that the scientific literature suggests this may be more beneficial for forming a vivid response to the description.

Dr Elspeth Jajdelska, a lecturer in Strathclyde's Faculty of Humanities & Social Sciences, led the research. She said: "Faces are something we perceive in a different way to other objects.

"Psychological research shows that we perceive and process them as a whole, not as a set of features, and while some literary descriptions of a face supply pieces of information to be assembled like a jigsaw puzzle, others may involve a holistic picture and an immediate response to what the author has described- these may not necessarily be accurate images, in terms of the face the author has in mind, but could still be very vivid.

"There is evidence to suggest that asking for a verbal description of a face can make it less easy for the face to be recognised and other research has called the effectiveness of the photofit identification technique into question- all suggesting that piece by piece descriptions of a face may not be the ideal way to communicate face information in words.

"However, a writer's description might produce a vivid response with only a partial description if it is also holistic, or draws on emotional qualities of the face."

One of the descriptions examined was of Bill Sikes, the character in Dickens' Oliver Twist, whose black eye is said to have "displayed various parti-coloured symptoms of having been recently damaged by a blow." The researchers suggested that this description could be more vivid than one which was more precise about the discolouration.

The researchers' theory defined 'vividness' in several ways, including: something belonging to a stimulus, such as a piece of text; an emotional experience produced by such a stimulus, or how realistic the mental images produced by text are.

Dr Steve Kelly, a Senior Lecturer in Psychology in Strathclyde's Faculty of Humanities & Social Sciences, was a research partner in the project. Researchers from the University of Oxford, the University of Edinburgh and Glasgow Caledonian University were also involved.

The research paper has been published in the journal Poetics Today.

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Biggest ever study shows no link between mobile phone use and tumors

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ScienceDaily (Oct. 20, 2011) — There is no link between long-term use of mobile phones and tumours of the brain or central nervous system, finds new research published online in the British Medical Journal.

In what is described as the largest study on the subject to date, Danish researchers found no evidence that the risk of brain tumours was raised among 358,403 mobile phone subscribers over an 18-year period.

The number of people using mobile phones is constantly rising with more than five billion subscriptions worldwide in 2010. This has led to concerns about potential adverse health effects, particularly tumours of the central nervous system.

Previous studies on a possible link between phone use and tumours have been inconclusive particularly on long-term use of mobile phones. Some of this earlier work took the form of case control studies involving small numbers of long-term users and were shown to be prone to error and bias. The International Agency for Research on Cancer (IARC) recently classified radio frequency electromagnetic fields, as emitted by mobile phones, as possibly carcinogenic to humans.

The only cohort study investigating mobile phone use and cancer to date is a Danish nationwide study comparing cancer risk of all 420,095 Danish mobile phone subscribers from 1982 until 1995, with the corresponding risk in the rest of the adult population with follow-up to 1996 and then 2002. This study found no evidence of any increased risk of brain or nervous system tumours or any cancer among mobile phone subscribers.

So researchers, led by the Institute of Cancer Epidemiology in Copenhagen, continued this study up to 2007.

They studied data on the whole Danish population aged 30 and over and born in Denmark after 1925, subdivided into subscribers and non-subscribers of mobile phones before 1995. Information was gathered from the Danish phone network operators and from the Danish Cancer Register.

Overall, 10,729 central nervous system tumours occurred in the study period 1990-2007.

When the figures were restricted to people with the longest mobile phone use -- 13 years or more -- cancer rates were almost the same in both long-term users and non-subscribers of mobile phones.

The researchers say they observed no overall increased risk for tumours of the central nervous system or for all cancers combined in mobile phone users.

They conclude: "The extended follow-up allowed us to investigate effects in people who had used mobile phones for 10 years or more, and this long-term use was not associated with higher risks of cancer.

"However, as a small to moderate increase in risk for subgroups of heavy users or after even longer induction periods than 10-15 years cannot be ruled out, further studies with large study populations, where the potential for misclassification of exposure and selection bias is minimised, are warranted."

In an accompanying editorial, Professors Anders Ahlbom and Maria Feychting at the Karolinska Institutet in Sweden say this new evidence is reassuring, but continued monitoring of health registers and prospective cohorts is still warranted.

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The above story is reprinted from materials provided by BMJ-British Medical Journal.

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Journal References:

P. Frei, A. H. Poulsen, C. Johansen, J. H. Olsen, M. Steding-Jessen, J. Schuz. Use of mobile phones and risk of brain tumours: update of Danish cohort study. BMJ, 2011; 343 (oct19 4): d6387 DOI: 10.1136/bmj.d6387A. Ahlbom, M. Feychting. Mobile telephones and brain tumours. BMJ, 2011; 343 (oct19 4): d6605 DOI: 10.1136/bmj.d6605

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Wednesday, 2 November 2011

'Trading places' most common pattern for couples dealing with male depression

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ScienceDaily (Oct. 21, 2011) — University of British Columbia researchers have identified three major patterns that emerge among couples dealing with male depression. These can be described as "trading places," "business as usual" and "edgy tensions."

Published in the Social Science & Medicine journal and led by UBC researcher John Oliffe, the paper details how heterosexual couples' gender roles undergo radical shifts and strain when the male partner is depressed and the female partner seeks to help. Depression, a disorder often thought of as a women's health issue, is underreported in men, and little is known about how heterosexual couples respond when the male partner is depressed.

"Overall, our study underscores how women play a key role in helping their male partners manage their depression," says Oliffe, an associate professor in the School of Nursing whose work investigates masculinities and men's health with a focus on men's depression.

"Our findings suggest that gender relations are pivotal in how health decisions are made in families and for that reason, it's important to understand couple dynamics if we want to have effective interventions."

Oliffe and his UBC colleagues found that "trading places" is the most common pattern. In these relationships, the partners took on atypical masculine and feminine roles to cope with challenges caused by the men's depression. For instance, men assumed the role of homemaker while the women became the family breadwinner.

Oliffe says, "Here, women partners also broke with feminine ideals in how they provided partner support by employing tough love strategies for self-protection and a means of prompting the men's self-management of their depression."

The second most common pattern is "business as usual," when couples sought to downplay or mask any problems caused by the men's depression. Holding firm to idealized heterosexual gender roles, the women continued to support and nurture their partners. Despite their ongoing struggles with depression, the men continued to work hard to maintain their careers in typically masculine arenas, which in the study included engineering, science, law enforcement, forestry and coaching.

The third pattern, "edgy tensions," describes men and women caught in dysfunctional relationships. Each holding ideas of gender roles that differed from those of their partner, these couples grappled with resentment. The men resisted medical treatment. Instead, they used alcohol and illicit drugs, at least in part, to self-manage their depression. The women expressed ambivalence about conforming to the feminine ideal of being a "selfless nurturer," especially for men who were volatile and unpredictable. The men in turn espoused a view of themselves as head of the household.

The study conducted qualitative analysis through in-depth interviews with 26 men, diagnosed or self identified as depressed, and their 26 partners, from Prince George, Kelowna and Vancouver. The study participants ranged in age from 20 to 53 years old. The duration of the couples' relationships ranged from two months to 18 years; seven couples had children living at home.

The men self-identified as Anglo-Canadian, First Nations, European, Asian and Middle Eastern. Seven couples were in mixed ethnicity relationships. The men had varying levels of education ranging from some high school to graduate degrees; 14 of the 26 men were unemployed at the time of interview, and self-identified as being of low socio-economic status as a consequence.

This research received support through the Canadian Institutes of Health Research, Institute of Gender and Health.

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John L. Oliffe, Mary T. Kelly, Joan L. Bottorff, Joy L. Johnson, Sabrina T. Wong. "He’s more typically female because he’s not afraid to cry": Connecting heterosexual gender relations and men’s depression. Social Science & Medicine, 2011; 73 (5): 775 DOI: 10.1016/j.socscimed.2011.06.034

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How do protein binding sites stay dry in water?

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ScienceDaily (Oct. 21, 2011) — In a report to be published soon in The European Physical Journal E, researchers from the National University of the South in Bahía Blanca, Argentina studied the condition for model cavity and tunnel structures resembling the binding sites of proteins to stay dry without losing their ability to react, a prerequisite for proteins to establish stable interactions with other proteins in water.

E.P. Schulz and colleagues used models of nanometric-scale hydrophobic cavities and tunnels to understand the influence of geometry on the ability of those structures to stay dry in solution.

The authors studied the filling tendency of cavities and tunnels carved in a system referred to as an alkane-like monolayer, chosen for its hydrophobic properties, to ensure that no factors other than geometrical constraints determine their ability to stay dry.

They determined that the minimum size of hydrophobic cavities and tunnels that can be filled with water is on the order of a nanometer. Below that scale, these structures stay dry because they provide a geometric shield; if a water molecule were to penetrate the cavity it would pay the excessive energy cost of giving up its hydrogen bonds. By comparison, water fills carbon nanotubes that are twice as small (but slightly less hydrophobic) than the alkane monolayer, making them less prone to stay dry.

The authors also showed that the filling of nanometric cavities and tunnels with water is a dynamic process that goes from dry to wet over time. They believe that water molecules inside the cavities or tunnels are arranged in a network of strong cooperative hydrogen bonds. Their disruption by means of thermal fluctuations results in the temporary drying of the holes until new bonds are re-established.

One of the many potential applications is in biophysics, to study water-exclusion sites of proteins, and understand the physical phenomenon linked to the geometry of those sites, underpinning the widespread biological process of protein-protein associations.

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E. P. Schulz, L. M. Alarcón, G. A. Appignanesi. Behavior of water in contact with model hydrophobic cavities and tunnels and carbon nanotubes. The European Physical Journal E, 2011; 34 (10) DOI: 10.1140/epje/i2011-11114-8

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Biomarker detects graft-versus-host-disease in cancer patients after bone marrow transplant

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ScienceDaily (Oct. 21, 2011) — A University of Michigan Health System-led team of researchers has found a biomarker they believe can help rapidly identify one of the most serious complications in patients with leukemia, lymphoma and other blood disorders who have received a transplant of new, blood-forming cells.

Known as a hematopoietic stem cell transplant, these patients receive bone marrow or peripheral blood stem cells from a matched donor who is either a family member or an unrelated volunteer.

The most common fatal complication of this type of transplant is graft-versus-host disease (GVHD), where the newly transplanted immune system of the donor attacks the patient's skin and internal organs. Up to 30 percent of recipients develop GVHD in their gastrointestinal tract, which is the organ most resistant to treatment.

Without invasive tests such as biopsies, however, GVHD can be difficult to distinguish from other causes of gastrointestinal distress, such as infection or side effects from medication.

The U-M team tested blood samples from over 1,000 patients who were treated in Ann Arbor, Germany and Japan.

"We believe we've found a reliable biomarker in the patients' blood that is specific to graft-versus-host disease and therefore can help us to rapidly identify patients for whom standard treatment is likely to be insufficient," says James L.M. Ferrara, M.D., co-lead author of the study and director of the U-M Combined Blood and Marrow Transplant Program. "This marker can also tell us whether a patient is likely to respond to therapy and may lead to an entirely new risk assessment for the disease. The findings were recently published online ahead of print publication in the journal Blood.

The marker, known as regenerating islet-derived 3-alpha (REG3-alpha), doesn't prevent patients from still needing a biopsy, Ferrara cautions, but taken with other predictive indicators, it could help doctors to ensure patients get the most appropriate treatment as early as possible.

Doctors at U-M hope to start using the test clinically in early 2012.

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J. L. M. Ferrara, A. C. Harris, J. K. Greenson, T. M. Braun, E. Holler, T. Teshima, J. E. Levine, S. W. J. Choi, E. Huber, K. Landfried, K. Akashi, M. Vander Lugt, P. Reddy, A. Chin, Q. Zhang, S. Hanash, S. Paczesny. Regenerating islet-derived 3 alpha is a biomarker of gastrointestinal graft-versus-host disease. Blood, 2011; DOI: 10.1182/blood-2011-08-375006

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Aggregating bandwidth for faster mobile networks

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ScienceDaily (Oct. 21, 2011) — Smart phones, tablet computers and mobile broadband have begun to shift the mobile communications industry into a new phase especially as global mobile data traffic had already exceed voice traffic by the end of 2009.

A new study published in the Int. J. Management and Network Economics reveals that the value of mobile spectrum, the capacity to transfer data across mobile networks, is only likely to increase as the demand for data transfer increases. However, it is only those telecommunications companies that bought up in government auctions the inexpensive licences to operate at particularly frequencies of the spectrum that will be in strong position to dominate in the consumer and enterprise markets as well as being in a position to lease bandwidth to their competitors at a high profit.

Jan Markendahl of the Royal Institute of Technology and Bengt G. Mölleryd of the Swedish Post and Telecom Agency in Stockholm have demonstrated that operators that are able to obtain more spectrum than their competitors, and pursue network sharing and spectrum aggregation have a competitive advantage as they have the lowest production cost, highest margin and highest capacity when usage takes off. Spectrum is much cheaper than the construction of new base stations, network towers, power, and site leases.

With the emergence of new radio technology that allows otherwise separate blocks of frequencies to be used as if they were a single block of bandwidth means will allow those operators who enable the so-called 3GPP standard to profit from the separate chunks of bandwidth they own. Similarly, the evolution of 4G technology and devices will also allow aggregation. Indeed, the mobile equipment manufacturers have already launched flexible radio equipment capable of handling all relevant frequencies and access technologies.

Data traffic across mobile networks in Sweden alone increased by more than 90% during 2010 compared to 2009, from 27,800 to 53,100 terabytes (TB). Similar increases are being experienced elsewhere. The figures are likely to rise even faster in coming years as more people opt for smartphones and the use of tablet computers becomes more widespread. Such operators are likely to benefit considerably from this growth.

The researchers point out that the level of data rates a company can offer will be pivotal for its marketing success in mobile broadband services. Even minor differences will be exploited to gain brand advantage and those operators who can best use the entire spectrum available to them will be able to beat their competitors on data speeds. As the technology evolves, the companies that bought up lots of separate chunks of spectrum in the cheap government sell-offs of bandwidth could gain the upper hand.

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Tuesday, 1 November 2011

NIPPV linked to increased hospital mortality rates in small group of patients

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ScienceDaily (Oct. 21, 2011) — Although increased use of noninvasive positive-pressure ventilation (NIPPV) nationwide has helped decrease mortality rates among patients hospitalized with chronic obstructive pulmonary disease (COPD), a small group of patients requiring subsequent treatment with invasive mechanical ventilation (IMV) have a significantly higher risk of death than those placed directly on IMV, according to researchers in the United States who studied patterns of NIPPV use.

The findings were published online ahead of the print edition of the American Thoracic Society's American Journal of Respiratory and Critical Care Medicine. Patients hospitalized with COPD frequently require mechanical ventilation -- either invasive or noninvasive -- to help them breathe. IMV requires insertion of a rigid tube into the airway which allows oxygen to enter and exit the lungs freely. Invasive methods often involve a significant risk of infection which can occur when bacteria gather around the tube and its fittings. As a result, NIPPV methods are used when possible to minimize infection risks. NIPPV relies on the use of a mask to deliver pressurized air through the mouth and nose. The two common forms of NIPPV are continuous positive airway pressure (CPAP), which provides a continuous pressurized stream of air, and bilevel positive airway pressure (BPAP), which offers different pressures for inhalation and exhalation.

"We performed the first examination of the patterns and outcomes of NIPPV treatment for acute exacerbations of COPD in clinical practice nationwide, using data from an estimated 7,511,267 million hospital admissions in the United States during 1998-2008," said Fernando Holguin, MD, MPH, an assistant professor of medicine in the Pulmonary, Allergy and Critical Care Division at the University of Pittsburgh School of Medicine. "The current study, to the best of our knowledge, is the first to report a dramatic shift towards NIPPV use for treating respiratory failure from acute exacerbations in the United States." The increase is consistent with results reported by investigators in smaller studies, he said.

For this study, researchers from the University of Pittsburgh, Emory University, the University of Illinois at Chicago and the University of Kentucky reviewed clinical patient data gathered by the Healthcare Cost and Utilization Project Nationwide Inpatient Sample (HCUP-NIS) database between 1998 and 2008. The researchers examined changes in the frequency of NIPPV and IMV use from 1998 to 2008, and compared patient demographics, income status, payer type, hospital region and hospital type among patients who initially received NIPPV, IMV or no respiratory support after hospital admission. They also examined in-hospital mortality, length-of-stay and total hospitalization charges, and compared those outcomes among patient groups.

At the completion of the study, they found that although the annual number of hospitalizations for acute exacerbations remained relatively constant during the 10-year period, there was a progressive increase in the use of NIPPV and a progressive decrease in use of IMV; during the entire study period, there was a fourfold increase in the use of NIPPV, which had grown to overtake IMV as the most frequently used form of respiratory support for patients hospitalized with acute exacerbations in the United States.

They also found that despite a steady decline in mortality among most patients studied, patients who used NIPPV and were then transitioned to IMV had significantly higher mortality rates than other patients, and that the mortality rate in these transitioned patients increased during the study period while mortality rates of other groups declined. Patients in this group also experienced the greatest increase in hospital charges and longest hospital length-of-stay.

"The concerning finding in our analysis was the high mortality in the group of patients who, despite initial treatment with NIPPV, required subsequent placement on IMV," said Dr. Holguin, who also serves as the assistant director of the University of Pittsburgh Medical Center's Asthma Institute at the University of Pittsburgh School of Medicine. "It is notable that this finding is contrary to that found in the carefully monitored patient environment of clinical trials, where those transitioned from NIPPV to IMV did not have higher mortality than patients placed on IMV from the beginning."

Dr. Holguin added that the overall trend toward greater use of NIPPV was likely due to several factors, including clinical trials linking NIPPV with a decrease in hospital mortality, increased confidence in using NIPPV and the ability to use NIPPV outside of the intensive care unit. "These results suggest that healthcare providers should continue to be aggressive with the use of noninvasive ventilation for patients with acute exacerbations, but definitely should intensively monitor sick patients, intervene early in the absence of improvement, and carefully examine if transitioning to IMV is in the interest of a patient with a poor prognosis," he said.

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Journal Reference:

Chandra Divay et al. Outcomes of Non-invasive Ventilation for Acute Exacerbations of COPD in the United States, 1998-2008. American Journal of Respiratory and Critical Care Medicine, 2011

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